Mutation of Tyrosine Sites in the Human Alpha-Synuclein Gene Induces Neurotoxicity in Transgenic Mice with Soluble Alpha-Synuclein Oligomer Formation

Overexpression of α-synuclein with tyrosine mutated to phenylalanine at position 125 leads to a severe phenotype with motor impairment and neuropathology in <i>Drosophila</i>. Here, we hypothesized that tyrosine mutations would similarly lead to impaired motor performance with neuropatho...

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發表在:	Cells
Main Authors:	Louise Berkhoudt Lassen, Maj Schneider Thomsen, Elisa Basso, Ernst-Martin Füchtbauer, Annette Füchtbauer, Tiago Fleming Outeiro, Poul Henning Jensen, Torben Moos
格式:	Article
語言:	英语
出版:	MDPI AG 2022-11-01
主題:	Parkinson’s disease alpha-synuclein neurodegeneration tyrosine serine transgene
在線閱讀:	https://www.mdpi.com/2073-4409/11/22/3673