Enhancing antitumor efficacy of oncolytic virus M1 via albendazole-sustained CD8+ T cell activation

The immune response plays a crucial role in the functionality of oncolytic viruses. In this study, Albendazole, an antihelminthic drug known to modulate the immune checkpoint PD-L1, was combined with the oncolytic virus M1 (OVM1) to treat mice with either prostate cancer (RM-1) or glioma (GL261) tum...

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Bibliographic Details

Published in:	Molecular Therapy: Oncology
Main Authors:	Wenjing Bai, Xia Tang, Tong Xiao, Yangyang Qiao, Xuyan Tian, Bo Zhu, Jiehong Chen, Chaoxin Chen, Yuanyuan Li, Xueying Lin, Jing Cai, Yuan Lin, Wenbo Zhu, Guangmei Yan, Jiankai Liang, Jun Hu
Format:	Article
Language:	English
Published:	Elsevier 2024-06-01
Subjects:	oncolytic virus albendazole CD8+T anti-tumor CTLA4
Online Access:	http://www.sciencedirect.com/science/article/pii/S2950329924000559