The homeodomain regulates stable DNA binding of prostate cancer target ONECUT2

Abstract The CUT and homeodomain are ubiquitous DNA binding elements often tandemly arranged in multiple transcription factor families. However, how the CUT and homeodomain work concertedly to bind DNA remains unknown. Using ONECUT2, a driver and therapeutic target of advanced prostate cancer, we sh...

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Bibliographic Details

Published in:	Nature Communications
Main Authors:	Avradip Chatterjee, Brad Gallent, Madhusudhanarao Katiki, Chen Qian, Matthew R. Harter, Steve Silletti, Elizabeth A. Komives, Michael R. Freeman, Ramachandran Murali
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-10-01
Online Access:	https://doi.org/10.1038/s41467-024-53159-8