Efficient enzymatic synthesis of (S)-1-(3′-bromo-2′-methoxyphenyl)ethanol, the key building block of lusutrombopag

(S)-1-(3′-Bromo-2′-methoxyphenyl)ethanol ((S)-1b) is the key precursor for the synthesis of Lusutrombopag. The bioreduction of 1-(3′-bromo-2′-methoxyphenyl)ethanone (1a) offers an attractive method to access this important compound. Through screening the available carbonyl reductases, we obtained a...

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Bibliographic Details

Published in:	Green Synthesis and Catalysis
Main Authors:	Yunfeng Cui, Yangyang Ji, Xi Chen, Jianjiong Li, Jinhui Feng, Qing Zhao, Peiyuan Yao, Qiaqing Wu, Dunming Zhu
Format:	Article
Language:	English
Published:	KeAi Communications Co. Ltd. 2023-08-01
Subjects:	Biocatalysis Carbonyl reductase Asymmetric reduction Chiral aryl alcohols Lusutrombopag
Online Access:	http://www.sciencedirect.com/science/article/pii/S2666554922000722