Uncoupling of Voltage- and Ligand-Induced Activation in HCN2 Channels by Glycine Inserts

Hyperpolarization-activated cyclic nucleotide-modulated (HCN) channels are tetramers that generate electrical rhythmicity in special brain neurons and cardiomyocytes. The channels are activated by membrane hyperpolarization. The binding of cAMP to the four available cyclic nucleotide-binding domains...

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Bibliographic Details

Published in:	Frontiers in Physiology
Main Authors:	Sezin Yüksel, Michele Bonus, Tina Schwabe, Christopher Pfleger, Thomas Zimmer, Uta Enke, Inga Saß, Holger Gohlke, Klaus Benndorf, Jana Kusch
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-08-01
Subjects:	HCN2 channels voltage-dependent gating cAMP-dependent gating autoinhibition patch-clamp technique confocal patch-clamp fluorometry
Online Access:	https://www.frontiersin.org/articles/10.3389/fphys.2022.895324/full