A Concise Total Synthesis of the Fungal Isoquinoline Alkaloid TMC-120B

Recent reports of antiepileptic activity of the fungal alkaloid TMC-120B have renewed the interest in this natural product. Previous total syntheses of TMC-120B comprise many steps and have low overall yields (11–17 steps, 1.5–2.9% yield). Thus, to access this compound more efficiently, we herein pr...

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Bibliographic Details

Published in:	Molecules
Main Authors:	Ahmad K. Haidar, Niels D. Kjeldsen, Nikolaj S. Troelsen, Viola Previtali, Kasper P. Lundquist, Thomas O. Larsen, Mads H. Clausen
Format:	Article
Language:	English
Published:	MDPI AG 2022-01-01
Subjects:	isoquinolines alkaloids epilepsy
Online Access:	https://www.mdpi.com/1420-3049/27/2/521