Protein Misfolding and Aggregation as a Therapeutic Target for Polyglutamine Diseases

The polyglutamine (polyQ) diseases, such as Huntington’s disease and several types of spinocerebellar ataxias, are a group of inherited neurodegenerative diseases that are caused by an abnormal expansion of the polyQ tract in disease-causative proteins. Proteins with an abnormally expanded polyQ str...

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Bibliographic Details

Published in:	Brain Sciences
Main Authors:	Toshihide Takeuchi, Yoshitaka Nagai
Format:	Article
Language:	English
Published:	MDPI AG 2017-10-01
Subjects:	polyglutamine diseases Huntington’s disease conformational change aggregation misfolding β-sheet monomer therapeutic target QBP1 molecular chaperone
Online Access:	https://www.mdpi.com/2076-3425/7/10/128