Hepatic TGFβr1 Deficiency Attenuates Lipopolysaccharide/D-Galactosamine–Induced Acute Liver Failure Through Inhibiting GSK3β–Nrf2–Mediated Hepatocyte Apoptosis and FerroptosisSummary

Background & Aims: Acute liver failure (ALF) is a condition with high mortality and morbidity, characterized by glutathione depletion, oxidative stress, and mitochondrial dysfunction. Ferroptosis may be involved in ALF. Indeed, emerging studies have shown that ferroptosis plays a significant...

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Bibliographic Details

Published in:	Cellular and Molecular Gastroenterology and Hepatology
Main Authors:	Sha Huang, Yuhua Wang, Shuwen Xie, Yuqi Lai, Chan Mo, Ting Zeng, Shanshan Kuang, Guanghui Deng, Chuying Zhou, Yuyao Chen, Shaohui Huang, Lei Gao, Zhiping Lv
Format:	Article
Language:	English
Published:	Elsevier 2022-01-01
Subjects:	ALF TGFβr1 Nrf2 GSK3β ROS Apoptosis
Online Access:	http://www.sciencedirect.com/science/article/pii/S2352345X22000364