Regiodivergent biosynthesis of bridged bicyclononanes

Abstract Medicinal compounds from plants include bicyclo[3.3.1]nonane derivatives, the majority of which are polycyclic polyprenylated acylphloroglucinols (PPAPs). Prototype molecules are hyperforin, the antidepressant constituent of St. John’s wort, and garcinol, a potential anticancer compound. Th...

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Bibliographic Details

Published in:	Nature Communications
Main Authors:	Lukas Ernst, Hui Lyu, Pi Liu, Christian Paetz, Hesham M. B. Sayed, Tomke Meents, Hongwu Ma, Ludger Beerhues, Islam El-Awaad, Benye Liu
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-05-01
Online Access:	https://doi.org/10.1038/s41467-024-48879-w