Lipoarabinomannan Decreases Galectin-9 Expression and Tumor Necrosis Factor Pathway in Macrophages Favoring Mycobacterium tuberculosis Intracellular Growth

Lipoarabinomannan (LAM) is a lipid virulent factor secreted by Mycobacterium tuberculosis (Mtb). LAM can be found in the sputum and urine of patients with active tuberculosis. When human monocytes are differentiated into macrophages [monocyte-derived macrophages (MDM)] in the presence of LAM, MDM ar...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Leslie Chávez-Galán, Lucero Ramon-Luing, Claudia Carranza, Irene Garcia, Isabel Sada-Ovalle
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2017-11-01
Subjects:	macrophage Mycobacterium tuberculosis lipoarabinomannan galectin-9 tumor necrosis factor pathway
Online Access:	http://journal.frontiersin.org/article/10.3389/fimmu.2017.01659/full