Therapy-induced senescent tumor cell-derived extracellular vesicles promote colorectal cancer progression through SERPINE1-mediated NF-κB p65 nuclear translocation

Abstract Background Cellular senescence frequently occurs during anti-cancer treatment, and persistent senescent tumor cells (STCs) unfavorably promote tumor progression through paracrine secretion of the senescence-associated secretory phenotype (SASP). Extracellular vesicles (EVs) have recently em...

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出版年:	Molecular Cancer
主要な著者:	Dan Zhang, Jian-Wei Zhang, Hui Xu, Xin Chen, Yu Gao, Huan-Gang Jiang, You Wang, Han Wu, Lei Yang, Wen-Bo Wang, Jing Dai, Ling Xia, Jin Peng, Fu-Xiang Zhou
フォーマット:	論文
言語:	英語
出版事項:	BMC 2024-04-01
主題:	Cellular senescence Extracellular vesicles Colorectal cancer SERPINE1 p65
オンライン･アクセス:	https://doi.org/10.1186/s12943-024-01985-1