Extracellular vesicle surface engineering with integrins (ITGAL & ITGB2) to specifically target ICAM-1-expressing endothelial cells

Abstract Extracellular vesicles (EVs) are taken up by most cells, however specific or preferential cell targeting remains a hurdle. This study aims to develop an EV that targets cells involved in inflammation, specifically those expressing intercellular adhesion molecule-1 (ICAM-1). To target these...

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发表在:	Journal of Nanobiotechnology
Main Authors:	Markus Bergqvist, Kyong-Su Park, Nasibeh Karimi, Lijuan Yu, Cecilia Lässer, Jan Lötvall
格式:	文件
语言:	英语
出版:	BMC 2025-01-01
主题:	Exosomes Genetic engineering Integrin aL Integrin b2 Targeting Peptide loading
在线阅读:	https://doi.org/10.1186/s12951-025-03125-3