Identification and immune characteristics of N6-methyladenosine related ferroptosis-related genes in intervertebral disc degeneration

Abstract The damage of ferroptosis is related to the pathogenesis of intervertebral disc degeneration (IDD). N6-methyladenosine (m6A) modification accounts for more than 80% of RNA modifications in eukaryotic cells. However, the key role of m6A related ferroptosis-related genes (FRGs) in IDD remain...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Zhen Che, Ruibing Chen, Ming Li, Zhuangyao Liao, Kun Wang, Dengbo Yao, Yuwei Liang, Yuxi Li, Guoming Wen, Tong Xing, Kaihui Su, Changchun Liang, Lin Huang, Qun Zhao
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-09-01
Subjects:	Intervertebral disc degeneration N6-methyladenosine Ferroptosis Immune
Online Access:	https://doi.org/10.1038/s41598-025-18011-z