Complement 3+-astrocytes are highly abundant in prion diseases, but their abolishment led to an accelerated disease course and early dysregulation of microglia

Abstract Astrogliosis and activation of microglia are hallmarks of prion diseases in humans and animals. Both were viewed to be rather independent events in disease pathophysiology, with proinflammatory microglia considered to be the potential neurotoxic species at late disease stages. Recent invest...

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Bibliographic Details

Published in:	Acta Neuropathologica Communications
Main Authors:	Kristin Hartmann, Diego Sepulveda-Falla, Indigo V. L. Rose, Charlotte Madore, Christiane Muth, Jakob Matschke, Oleg Butovsky, Shane Liddelow, Markus Glatzel, Susanne Krasemann
Format:	Article
Language:	English
Published:	BMC 2019-05-01
Subjects:	Prion diseases A1-astrocytes Microglia Neurotoxicity
Online Access:	http://link.springer.com/article/10.1186/s40478-019-0735-1