TLR7 Signaling Shapes and Maintains Antibody Diversity Upon Virus-Like Particle Immunization

Virus-like particles (VLPs) are used in different marketed vaccines and are able to induce potent antibody responses. The innate pattern recognition receptors TLR7/8 recognize single stranded (ss) RNA naturally packaged into some VLPs and have been shown to enhance the production of IgG antibodies u...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Xinyue Chang, Pascal Krenger, Caroline C. Krueger, Lisha Zha, Jiami Han, Alexander Yermanos, Salony Roongta, Mona O. Mohsen, Annette Oxenius, Monique Vogel, Martin F. Bachmann
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-01-01
Subjects:	Qβ-VLP Fel d 1 TLR7 B cell receptor repertoire hypermutation
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2021.827256/full