Stewart’s theory and acid–base changes induced by crystalloid infusion in humans: a randomized physiological trial

Abstract Background Stewart’s acid–base theory states that, under isocapnic conditions, crystalloid infusion affects plasma pH due to changes in strong ion difference and total weak acid concentration: a comprehensive study also assessing renal response and hemodilution effects has not been conducte...

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Bibliographic Details

Published in:	Annals of Intensive Care
Main Authors:	Antonio Maria Dell’Anna, Domenico Luca Grieco, Cristina Dominedò, Marta Cicetti, Irene Cisterna, Rossano Festa, Rosa Lamacchia, Giuseppina Giannì, Nicoletta Filetici, Teresa Michi, Cristina Rossi, Francesca Danila Alcaro, Alessandro Mele, Aurora Rocchi, Demetrio Del Prete, Maria Concetta Meluzio, Francesco Ciro Tamburrelli, Marco Rossi, Massimo Antonelli
Format:	Article
Language:	English
Published:	SpringerOpen 2025-04-01
Subjects:	Strong ion difference Stewart Chloride Acid–base balance Crystalloids
Online Access:	https://doi.org/10.1186/s13613-025-01473-9