Human β-Defensin 3 Inhibition of <i>P. gingivalis</i> LPS-Induced IL-1β Production by BV-2 Microglia through Suppression of Cathepsins B and L

Cathepsin B (CatB) is thought to be essential for the induction of <i>Porphyromonas gingivalis</i> lipopolysaccharide (<i>Pg</i> LPS)-induced Alzheimer’s disease-like pathologies in mice, including interleukin-1β (IL-1β) production and cognitive decline. However, little is kn...

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Bibliographic Details

Published in:	Cells
Main Authors:	Erika Inoue, Shiyo Minatozaki, Sachi Shimizu, Sayaka Miyamoto, Misato Jo, Junjun Ni, Hidetoshi Tozaki-Saitoh, Kosuke Oda, Saori Nonaka, Hiroshi Nakanishi
Format:	Article
Language:	English
Published:	MDPI AG 2024-02-01
Subjects:	BV-2 microglia cathepsin B CA-074Me human β-defensin 3 interleukin-1β lipopolysaccharide
Online Access:	https://www.mdpi.com/2073-4409/13/3/283