Paeonol protects against doxorubicin-induced cardiotoxicity by promoting Mfn2-mediated mitochondrial fusion through activating the PKCε-Stat3 pathway

Introduction: The anti-cancer medication doxorubicin (Dox) is largely restricted in clinical usage due to its significant cardiotoxicity. The only medication approved by the FDA for Dox-induced cardiotoxicity is dexrazoxane, while it may reduce the sensitivity of cancer cells to chemotherapy and is...

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Bibliographic Details

Published in:	Journal of Advanced Research
Main Authors:	Mingge Ding, Rui Shi, Feng Fu, Man Li, Dema De, Yanyan Du, Zongfang Li
Format:	Article
Language:	English
Published:	Elsevier 2023-05-01
Subjects:	Doxorubicin Paeonol Mitochondrial fusion PKCε Stat3 Mfn2
Online Access:	http://www.sciencedirect.com/science/article/pii/S2090123222001564