Dysbiosis in pregnant mice induced by transfer of human vaginal microbiota followed by reversal of pathological changes in the uterus and placenta via progesterone treatment

Abstract Objective The vaginal microbiota dysbiosis induces inflammation in the uterus that triggers tissue damage and is associated with preterm birth. Progesterone is used to prevent labor in pregnant women at risk of preterm birth. However, the mechanism of action of progesterone still needs to b...

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Bibliographic Details

Published in:	BMC Pregnancy and Childbirth
Main Authors:	Gulin Ozcan, Zeynep Gülçe Tanyolaç Talay, Erxiati Paerhati, Ozgur Can Eren, Nilhan Coskun, Deniz Sahin, Iman Alnajjar, Ozgur Albayrak, Attila Gursoy, Ozlem Keskin, Ebru Celik, Fusun Can
Format:	Article
Language:	English
Published:	BMC 2024-06-01
Subjects:	Vaginal microbiota Dysbiosis Pregnancy Preterm birth Inflammation Progesterone
Online Access:	https://doi.org/10.1186/s12884-024-06595-9