Differential Impact of the rpoB Mutant on Rifampin and Rifabutin Resistance Signatures of Mycobacterium tuberculosis Is Revealed Using a Whole-Genome Sequencing Assay

ABSTRACT Drug resistance in Mycobacterium tuberculosis (MTB) has long been a serious health issue worldwide. Most drug-resistant MTB isolates were identified due to treatment failure or in clinical examinations 3~6 months postinfection. In this study, we propose a whole-genome sequencing (WGS) pipel...

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Bibliographic Details
Published in:Microbiology Spectrum
Main Authors: Ming-Chih Yu, Ching-Sheng Hung, Chun-Kai Huang, Cheng-Hui Wang, Yu-Chih Liang, Jung-Chun Lin
Format: Article
Language:English
Published: American Society for Microbiology 2022-08-01
Subjects:
MinION
Mycobacterium tuberculosis
rifabutin
rifampin
rpoB
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00754-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.00754-22

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