Itaconate and obesity-related hormones promote tumor progression – new insights on metabolic dysfunction in early-onset colon cancer

IntroductionObesity is a strong risk factor for early-onset colon cancer (EOCC) and is associated with chronic inflammation largely mediated by macrophages. The macrophage-specific metabolite itaconate promotes growth in several types of cancer; however, its role in colon cancer (CC) is unknown. Her...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Katharina M. Scheurlen, Jacob Hallion, Dylan L. Snook, Anne MacLeod, Robert J. Beal, Mary A. Parks, Andrew B. Littlefield, Eliah Hiken, Adrian T. Billeter, Jeannette Bensen, Jeremy T. Gaskins, Julia Chariker, Eric C. Rouchka, Susan Galandiuk
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-06-01
Subjects:	early-onset colon cancer macrophages immunology obesity metabolism
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1572985/full