Basal pharmacokinetic parameters of topically applied diacerein in pediatric patients with generalized severe epidermolysis bullosa simplex

Abstract Generalized severe epidermolysis bullosa simplex (EBS-gen sev) is caused by mutations within either the KRT5 or KRT14 gene, phenotypically resulting in blistering and wounding of the skin and mucous membranes after minor mechanical friction. In a clinical phase 2/3 trial, diacerein has rece...

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Bibliographic Details
Published in:Orphanet Journal of Rare Diseases
Main Authors: Michael Ablinger, Thomas K. Felder, Monika Wimmer, Roland Zauner, Peter Hofbauer, Thomas Lettner, Martin Wolkersdorfer, Florian B. Lagler, Anja Diem, Johann W. Bauer, Verena Wally
Format: Article
Language:English
Published: BMC 2018-11-01
Subjects:
Epidermolysis bullosa
Diacerein
Topical application
Pharmacokinetics
Keratin
Online Access:http://link.springer.com/article/10.1186/s13023-018-0940-1

Internet

http://link.springer.com/article/10.1186/s13023-018-0940-1

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