Glucose stimulated CEST MRI pHe mapping for improved differentiation of tumors with altered hypoxia inducible factor 1alpha expression

Abstract Identification of highly aggressive tumors from benign phenotypes is an important diagnostic need, with increased expression of hypoxia-inducible factor-1α (HIF-1α) as one factor linked to tumor progression and treatment response. HIF-1α stabilization is closely linked to extracellular pH (...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Aruna Singh, Julia Stabinska, Balaji Krishnamachary, Farzad Sedaghat, Sridhar Nimmagadda, Jeff W. M. Bulte, Zaver M. Bhujwalla, Michael T. McMahon
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-08-01
Subjects:	Chemical exchange saturation transfer (CEST) pHe Hypoxia inducible factor-1α (HIF-1α) Iopamidol Breast cancer
Online Access:	https://doi.org/10.1038/s41598-025-14102-z