The β-Grasp Domain of Proteasomal ATPase Mpa Makes Critical Contacts with the Mycobacterium tuberculosis 20S Core Particle to Facilitate Degradation

ABSTRACT Mycobacterium tuberculosis possesses a Pup-proteasome system analogous to the eukaryotic ubiquitin-proteasome pathway. We have previously shown that the hexameric mycobacterial proteasome ATPase (Mpa) recruits pupylated protein substrates via interactions between amino-terminal coiled-coils...

Full description

Bibliographic Details
Published in:mSphere
Main Authors: Xiansha Xiao, Xiang Feng, Jin Hee Yoo, Amanda Kovach, K. Heran Darwin, Huilin Li
Format: Article
Language:English
Published: American Society for Microbiology 2022-10-01
Subjects:
ATPase
cryo-EM
Mycobacterium tuberculosis
proteasome
Online Access:https://journals.asm.org/doi/10.1128/msphere.00274-22

Internet

https://journals.asm.org/doi/10.1128/msphere.00274-22

Similar Items