Smurf2‐mediated degradation of EZH2 enhances neuron differentiation and improves functional recovery after ischaemic stroke

Abstract EZH2 plays an important role in stem cell renewal and maintenance by inducing gene silencing via its histone methyltransferase activity. Previously, we showed that EZH2 downregulation enhances neuron differentiation of human mesenchymal stem cells (hMSCs); however, the underlying mechanisms...

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Bibliographic Details

Published in:	EMBO Molecular Medicine
Main Authors:	Yung‐Luen Yu, Ruey‐Hwang Chou, Woei‐Cherng Shyu, Shu‐Ching Hsieh, Chen‐Shiou Wu, Shu‐Ya Chiang, Wei‐Jung Chang, Jia‐Ni Chen, Yen‐Ju Tseng, Yu‐Hsuan Lin, Wei Lee, Su‐Peng Yeh, Jennifer L. Hsu, Cheng‐Chieh Yang, Shih‐Chieh Hung, Mien‐Chie Hung
Format:	Article
Language:	English
Published:	Springer Nature 2013-03-01
Subjects:	EZH2 human mesenchymal stem cells (hMSCs) ischaemic neuronal injury neuron differentiation Smurf2
Online Access:	https://doi.org/10.1002/emmm.201201783