Diacerein ameliorates cholestasis-induced liver fibrosis in rat via modulating HMGB1/RAGE/NF-κB/JNK pathway and endoplasmic reticulum stress

Abstract Diacerein is an interleukin (IL)-1β inhibitor approved for osteoarthritis. This study aimed to investigate the potential anti-fibrotic effect of diacerein against bile duct ligation (BDL)-induced liver fibrosis. Forty male Wistar rats were divided into: sham-operated group, BDL group, and B...

وصف كامل

التفاصيل البيبلوغرافية

الحاوية / القاعدة:	Scientific Reports
المؤلفون الرئيسيون:	Amira Mohammed Abdelfattah, Shireen Sami Mahmoud, Dalia Ibrahim EL-wafaey, Heba Mahmoud Abdelgeleel, Amira Mohamed Abdelhamid
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	Nature Portfolio 2023-07-01
الوصول للمادة أونلاين:	https://doi.org/10.1038/s41598-023-38375-4