Effects of the dual orexin receptor antagonist DORA‐22 on sleep in 5XFAD mice

Abstract Introduction Sleep disruption is a characteristic of Alzheimer's disease (AD) that may exacerbate disease progression. This study tested whether a dual orexin receptor antagonist (DORA) would enhance sleep and attenuate neuropathology, neuroinflammation, and cognitive deficits in an AD...

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Bibliographic Details

Published in:	Alzheimer’s & Dementia: Translational Research & Clinical Interventions
Main Authors:	Marilyn J. Duncan, Hannah Farlow, Chairtra Tirumalaraju, Do‐Hyun Yun, Chanung Wang, James A. Howard, Madison N. Sanden, Bruce F. O'Hara, Kristen J. McQuerry, Adam D. Bachstetter
Format:	Article
Language:	English
Published:	Wiley 2019-01-01
Subjects:	Sleep‐wake cycles Sleep fragmentation Orexin Dual orexin receptor antagonist Amyloid β Neuroinflammation
Online Access:	https://doi.org/10.1016/j.trci.2019.01.003