Revealing the tissue-level complexity of endogenous glucagon-like peptide-1 receptor expression and signaling

Visualizing endogenous GPCRs is challenging. Here the authors generate mice with an enzyme self-label genome-edited into the endogenous glucagon-like peptide-1 receptor locus, design fluorescent dyes for specific labelling in complex tissue, and reveal tissue-level organisation and dynamics of an en...

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發表在:	Nature Communications
Main Authors:	Julia Ast, Daniela Nasteska, Nicholas H. F. Fine, Daniel J. Nieves, Zsombor Koszegi, Yann Lanoiselée, Federica Cuozzo, Katrina Viloria, Andrea Bacon, Nguyet T. Luu, Philip N. Newsome, Davide Calebiro, Dylan M. Owen, Johannes Broichhagen, David J. Hodson
格式:	Article
語言:	英语
出版:	Nature Portfolio 2023-01-01
在線閱讀:	https://doi.org/10.1038/s41467-022-35716-1