Nephrotoxic Effects in Zebrafish after Prolonged Exposure to Aristolochic Acid

With the aim to explore the possibility to generate a zebrafish model of renal fibrosis, in this study the fibrogenic renal effect of aristolochic acid I (AAI) after immersion was assessed. This compound is highly nephrotoxic able to elicit renal fibrosis after exposure of rats and humans. Our resul...

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Bibliographic Details

Published in:	Toxins
Main Authors:	Xixin Wang, Arianna Giusti, Annelii Ny, Peter A. de Witte
Format:	Article
Language:	English
Published:	MDPI AG 2020-03-01
Subjects:	zebrafish nephrotoxicity aristolochic acid fibrosis chronic kidney disorder
Online Access:	https://www.mdpi.com/2072-6651/12/4/217