Could MDMA Promote Stemness Characteristics in Mouse Embryonic Stem Cells via mGlu5 Metabotropic Glutamate Receptors?

Objective: Ecstasy, or 3, 4 (±) methylenedioxymethamphetamine (MDMA), is a potent neurotoxic drug. One of the mechanisms for its toxicity is the secondary release of glutamate. Mouse embryonic stem cells (mESCs) express only one glutamate receptor, the metabotropic glutamate receptor 5 (mGlu5), whic...

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Bibliographic Details

Published in:	Cell Journal
Main Authors:	Rokhsareh Meamar, Fereshte Karamali, Seyed Ali Mousavi, Hossein Baharvand, Mohammad Hossein Nasr-Esfahani
Format:	Article
Language:	English
Published:	Royan Institute (ACECR), Tehran 2012-01-01
Subjects:	Embryonic Stem Cells Ecstasy MDMA Self Renewal mGlu Receptor
Online Access:	http://celljournal.org/library/upload/article/af_22342544536222622223635735653634575342524-Meamar-1.pdf