Deep sequencing and flow cytometric characterization of expanded effector memory CD8+CD57+ T cells frequently reveals T-cell receptor Vβ oligoclonality and CDR3 homology in acquired aplastic anemia

Oligoclonal expansion of CD8+ CD28− lymphocytes has been considered indirect evidence for a pathogenic immune response in acquired aplastic anemia. A subset of CD8+ CD28− cells with CD57 expression, termed effector memory cells, is expanded in several immune-mediated diseases and may have a role in...

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Bibliographic Details

Published in:	Haematologica
Main Authors:	Valentina Giudice, Xingmin Feng, Zenghua Lin, Wei Hu, Fanmao Zhang, Wangmin Qiao, Maria del Pilar Fernandez Ibanez, Olga Rios, Neal S. Young
Format:	Article
Language:	English
Published:	Ferrata Storti Foundation 2018-05-01
Online Access:	https://haematologica.org/article/view/8446