Discovery of small-molecule positive allosteric modulators of Parkin E3 ligase

Summary: Pharmacological activation of the E3 ligase Parkin represents a rational therapeutic intervention for the treatment of Parkinson’s disease. Here we identify several compounds that enhance the activity of wildtype Parkin in the presence of phospho-ubiquitin and act as positive allosteric mod...

Full description

Bibliographic Details

Published in:	iScience
Main Authors:	Evgeny Shlevkov, Paramasivam Murugan, Dan Montagna, Eric Stefan, Adelajda Hadzipasic, James S. Harvey, P. Rajesh Kumar, Sonya Entova, Nupur Bansal, Shari Bickford, Lai-Yee Wong, Warren D. Hirst, Andreas Weihofen, Laura F. Silvian
Format:	Article
Language:	English
Published:	Elsevier 2022-01-01
Subjects:	Chemistry Biochemistry Biochemistry Applications
Online Access:	http://www.sciencedirect.com/science/article/pii/S2589004221016205