Constructing chimeric mouse islets to study alpha- and delta-cell influence on beta-cell feature

Objectives: This study aimed to evaluate the role of alpha- and delta-cell signals on beta-cells within pancreatic mouse islets. Specifically, we investigated how these signals regulate glucose sensitivity, gene expression and function in beta-cells. Methods: We first implemented our previous protoc...

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Bibliographic Details

Published in:	Molecular Metabolism
Main Authors:	Alexis Fouque, Masaya Oshima, Nina Mode, Romain Ducellier, Delphine Thibaut, Florence Gbahou, Latif Rachdi, Over Cabrera, Raphaël Scharfmann
Format:	Article
Language:	English
Published:	Elsevier 2025-11-01
Subjects:	Pancreas Islets Endocrine cells Chimeric clusters Insulin secretion
Online Access:	http://www.sciencedirect.com/science/article/pii/S2212877825001528