Contribution of the hexosamine biosynthetic pathway in the hyperglycemia-dependent and -independent breakdown of the retinal neurovascular unit

Background: Diabetic retinopathy (DR) remains one of the most common complications of diabetes despite great efforts to uncover its underlying mechanisms. The pathogenesis of DR is characterized by the deterioration of the neurovascular unit (NVU), showing damage of vascular cells, activation of gli...

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Bibliographic Details

Published in:	Molecular Metabolism
Main Authors:	Yixin Wang, Rachana Eshwaran, Susanne C. Beck, Hans-Peter Hammes, Thomas Wieland, Yuxi Feng
Format:	Article
Language:	English
Published:	Elsevier 2023-07-01
Subjects:	Hexosamine biosynthetic pathway Retinal neurovascular unit Hyperglycemia O-GlcNAc Endothelial cell Pericyte
Online Access:	http://www.sciencedirect.com/science/article/pii/S2212877823000704