A Novel Treatment for Glomerular Disease: Targeting the Activated Macrophage Folate Receptor with a Trojan Horse Therapy in Rats

Since activated macrophages express a functional folate receptor β (FRβ), targeting this macrophage population with folate-linked drugs could increase selectivity to treat inflammatory diseases. Using a macrophage-mediated anti-glomerular basement membrane (anti-GBM) glomerulonephritis (GN) in WKY r...

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書誌詳細

出版年:	Cells
主要な著者:	Gabriela E. Garcia, Yingjuan J. Lu, Luan D. Truong, Carlos A. Roncal-Jiménez, Makoto Miyazaki, Shinobu Miyazaki-Anzai, Gabriel Cara-Fuentes, Ana Andres-Hernando, Miguel Lanaspa, Richard J. Johnson, Christopher P. Leamon
フォーマット:	論文
言語:	英語
出版事項:	MDPI AG 2021-08-01
主題:	macrophages folate receptor glomerulonephritis inflammation aminopterin fibrosis
オンライン･アクセス:	https://www.mdpi.com/2073-4409/10/8/2113