Direct Arp2/3-vinculin binding is required for pseudopod extension, but only on compliant substrates and in 3D

Summary: A critical step in cell morphogenesis is the extension of actin-dense pseudopods, controlled by actin-binding proteins (ABPs). While this process is well-understood on glass coverslips, it is less so in compliant three-dimensional environments. Here, we knocked out a series of ABPs in osteo...

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Bibliographic Details

Published in:	iScience
Main Authors:	Tadamoto Isogai, Kevin M. Dean, Philippe Roudot, Evgenia V. Azarova, Kushal Bhatt, Meghan K. Driscoll, Shaina P. Royer, Nikhil Mittal, Bo-Jui Chang, Sangyoon J. Han, Reto Fiolka, Gaudenz Danuser
Format:	Article
Language:	English
Published:	Elsevier 2025-06-01
Subjects:	Biological morphology Molecular biology Cell biology
Online Access:	http://www.sciencedirect.com/science/article/pii/S2589004225008843