Decreased expression of Rev-Erbα in the epileptic foci of temporal lobe epilepsy and activation of Rev-Erbα have anti-inflammatory and neuroprotective effects in the pilocarpine model

Abstract Background A hallmark of temporal lobe epilepsy (TLE) is brain inflammation accompanied by neuronal demise. Accumulating evidence demonstrates that Rev-Erbα is involved in regulating neuroinflammation and determining the fate of neurons. Therefore, we studied the expression and cellular dis...

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Bibliographic Details

Published in:	Journal of Neuroinflammation
Main Authors:	Jiong Yue, Jiaojiang He, Yujia Wei, Kaifeng Shen, Kefu Wu, Xiaolin Yang, Shiyong Liu, Chunqing Zhang, Hui Yang
Format:	Article
Language:	English
Published:	BMC 2020-01-01
Subjects:	Temporal lobe epilepsy Rev-Erbα NLRP3 inflammasome Neuroinflammation Neuronal apoptosis
Online Access:	https://doi.org/10.1186/s12974-020-1718-7