Effects of APOE Genotype on Brain Proteomic Network and Cell Type Changes in Alzheimer's Disease

Polymorphic alleles in the apolipoprotein E (APOE) gene are the main genetic determinants of late-onset Alzheimer's disease (AD) risk. Individuals carrying the APOE E4 allele are at increased risk to develop AD compared to those carrying the more common E3 allele, whereas those carrying the E2...

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Bibliographic Details

Published in:	Frontiers in Molecular Neuroscience
Main Authors:	Jingting Dai, Erik C. B. Johnson, Eric B. Dammer, Duc M. Duong, Marla Gearing, James J. Lah, Allan I. Levey, Thomas S. Wingo, Nicholas T. Seyfried
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2018-12-01
Subjects:	Alzheimer's disease proteomics apolipoprotein E inflammation deconvolution
Online Access:	https://www.frontiersin.org/article/10.3389/fnmol.2018.00454/full