Familial ALS-associated SFPQ variants promote the formation of SFPQ cytoplasmic aggregates in primary neurons

Splicing factor proline- and glutamine-rich (SFPQ) is a nuclear RNA-binding protein that is involved in a wide range of physiological processes including neuronal development and homeostasis. However, the mislocalization and cytoplasmic aggregation of SFPQ are associated with the pathophysiology of...

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Bibliographic Details

Published in:	Open Biology
Main Authors:	Jocelyn Widagdo, Saumya Udagedara, Nishita Bhembre, Jing Zhi Anson Tan, Lara Neureiter, Jie Huang, Victor Anggono, Mihwa Lee
Format:	Article
Language:	English
Published:	The Royal Society 2022-09-01
Subjects:	amyotrophic lateral sclerosis protein aggregation DBHS proteins glutamate receptors RNA binding proteins zinc
Online Access:	https://royalsocietypublishing.org/doi/10.1098/rsob.220187