Targeting NINJ1-mediated cell rupture to treat inflammatory diseases

Abstract Cell death can terminate in plasma membrane rupture to release potent pro-inflammatory intracellular contents thereby contributing to inflammatory diseases. Cell rupture is an active process, mediated by the membrane protein ninjurin-1 (NINJ1) in pyroptosis, post-apoptosis lysis, ferroptosi...

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Bibliographic Details
Published in:Molecular Medicine
Main Authors: Claire Ju-Eun Hur, Benjamin Ethan Steinberg
Format: Article
Language:English
Published: BMC 2025-02-01
Subjects:
Cell death
Inflammation
Pyroptosis
Necrosis
Ferroptosis
NINJ1
Online Access:https://doi.org/10.1186/s10020-025-01113-9

Internet

https://doi.org/10.1186/s10020-025-01113-9

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