Skeletal myotube-derived extracellular vesicles enhance itaconate production and attenuate inflammatory responses of macrophages

IntroductionMacrophages play an important role in the innate immunity. While macrophage inflammation is necessary for biological defense, it must be appropriately controlled. Extracellular vesicles (EVs) are small vesicles released from all types of cells and play a central role in intercellular com...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Atomu Yamaguchi, Noriaki Maeshige, Jiawei Yan, Xiaoqi Ma, Mikiko Uemura, Mami Matsuda, Yuya Nishimura, Tomohisa Hasunuma, Hiroyo Kondo, Hidemi Fujino, Zhi-Min Yuan
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-03-01
Subjects:	extracellular vesicle skeletal muscle macrophage itaconate IRG1
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1099799/full