DNA hypomethylation-mediated upregulation of GADD45B facilitates airway inflammation and epithelial cell senescence in COPD

Introduction: Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease typically characterized by chronic airway inflammation, with emerging evidence highlighting the driving role of cellular senescence-related lung aging. Accelerated lung aging and inflammation mutually reinforce eac...

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Bibliographic Details

Published in:	Journal of Advanced Research
Main Authors:	Yuan Zhan, Qian Huang, Zhesong Deng, Shanshan Chen, Ruonan Yang, Jiaheng Zhang, Yating Zhang, Maocuo Peng, Jixing Wu, Yiya Gu, Zhilin Zeng, Jungang Xie
Format:	Article
Language:	English
Published:	Elsevier 2025-02-01
Subjects:	GADD45B Inflammation Cellular senescence DNA methylation Chronic obstructive pulmonary disease
Online Access:	http://www.sciencedirect.com/science/article/pii/S2090123224000675