TMIGD2 is an orchestrator and therapeutic target on human acute myeloid leukemia stem cells

Abstract Acute myeloid leukemia (AML) is initiated and sustained by a hierarchy of leukemia stem cells (LSCs), and elimination of this cell population is required for curative therapies. Here we show that transmembrane and immunoglobulin domain containing 2 (TMIGD2), a recently discovered co-stimula...

Full description

Bibliographic Details

Published in:	Nature Communications
Main Authors:	Hao Wang, R. Alejandro Sica, Gurbakhash Kaur, Phillip M. Galbo, Zhixin Jing, Christopher D. Nishimura, Xiaoxin Ren, Ankit Tanwar, Bijan Etemad-Gilbertson, Britta Will, Deyou Zheng, David Fooksman, Xingxing Zang
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-01-01
Online Access:	https://doi.org/10.1038/s41467-023-43843-6