Chloride channel-3 regulates sodium-iodide symporter expression and localization in the thyroids of mice on a high-iodide diet

IntroductionCertain chloride channels and H+/Cl− antiporters, such as chloride channel 3 (ClC-3), are expressed at the apical pole of thyrocytes, facilitating iodide (I−) efflux. However, the relationship between ClC-3 and I− uptake remains unclear. Additionally, whether ClC-3 and reactive oxygen sp...

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Bibliographic Details

Published in:	Frontiers in Nutrition
Main Authors:	Meisheng Yu, Zhiqin Deng, Ke Wang, Xiangzhong Zhang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-03-01
Subjects:	chloride channel 3 sodium-iodide symporter reactive oxygen species iodide excess thyroid gland iodide conditions
Online Access:	https://www.frontiersin.org/articles/10.3389/fnut.2025.1537221/full