The Guanylate Cyclase C—cGMP Signaling Axis Opposes Intestinal Epithelial Injury and Neoplasia

Guanylate cyclase C (GUCY2C) is a transmembrane receptor expressed on the luminal aspect of the intestinal epithelium. Its ligands include bacterial heat-stable enterotoxins responsible for traveler's diarrhea, the endogenous peptide hormones uroguanylin and guanylin, and the synthetic agents,...

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Bibliographic Details
Published in:Frontiers in Oncology
Main Authors: Jeffrey A. Rappaport, Scott A. Waldman
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Subjects:
guanylate cyclase C
cGMP
intestinal epithelium
colorectal cancer
microbiome
DNA repair
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2018.00299/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2018.00299/full

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