Targeting efflux pumps prevents the multi-step evolution of high-level resistance to fluoroquinolone in Pseudomonas aeruginosa

ABSTRACT Antibiotic resistance is emerging as a significant global health crisis, necessitating the urgent development of novel antibiotics or alternative therapies. Although it is recognized that bacteria require multiple mutations to develop resistance levels exceeding the mutant prevention concen...

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Bibliographic Details

Published in:	Microbiology Spectrum
Main Authors:	Xiao-Quan Yu, Hao Yang, Han-Zhong Feng, Jun Hou, Jun-Qiang Tian, Shao-Min Niu, Chong-Ge You, Xuan-Yu Tao, Si-Ping Zhang, Zhi-Ping Wang, Yong-Xing He
Format:	Article
Language:	English
Published:	American Society for Microbiology 2025-04-01
Subjects:	antimicrobial resistance evolution efflux pump Pseudomonas aeruginosa
Online Access:	https://journals.asm.org/doi/10.1128/spectrum.02981-24