HDX-MS reveals nucleotide-dependent, anti-correlated opening and closure of SecA and SecY channels of the bacterial translocon

The bacterial Sec translocon is a multi-protein complex responsible for translocating diverse proteins across the plasma membrane. For post-translational protein translocation, the Sec-channel – SecYEG – associates with the motor protein SecA to mediate the ATP-dependent transport of pre-proteins ac...

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Bibliographic Details

Published in:	eLife
Main Authors:	Zainab Ahdash, Euan Pyle, William John Allen, Robin A Corey, Ian Collinson, Argyris Politis
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2019-07-01
Subjects:	hydrogen-deuterium exchange mass spectromtery conformational dynamics SecA SecYEG protein translocation
Online Access:	https://elifesciences.org/articles/47402