HDX-MS reveals nucleotide-dependent, anti-correlated opening and closure of SecA and SecY channels of the bacterial translocon

The bacterial Sec translocon is a multi-protein complex responsible for translocating diverse proteins across the plasma membrane. For post-translational protein translocation, the Sec-channel – SecYEG – associates with the motor protein SecA to mediate the ATP-dependent transport of pre-proteins ac...

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書誌詳細

出版年:	eLife
主要な著者:	Zainab Ahdash, Euan Pyle, William John Allen, Robin A Corey, Ian Collinson, Argyris Politis
フォーマット:	論文
言語:	英語
出版事項:	eLife Sciences Publications Ltd 2019-07-01
主題:	hydrogen-deuterium exchange mass spectromtery conformational dynamics SecA SecYEG protein translocation
オンライン･アクセス:	https://elifesciences.org/articles/47402