Increased N-glycosylation efficiency by generation of an aromatic sequon on N135 of antithrombin.

The inefficient glycosylation of consensus sequence on N135 in antithrombin explains the two glycoforms of this key anticoagulant serpin found in plasma: α and β, with four and three N-glycans, respectively. The lack of this N-glycan increases the heparin affinity of the β-glycoform. Recent studies...

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Bibliographic Details

Published in:	PLoS ONE
Main Authors:	Sonia Aguila, Irene Martínez-Martínez, Gilda Dichiara, Ricardo Gutiérrez-Gallego, José Navarro-Fernández, Vicente Vicente, Javier Corral
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2014-01-01
Online Access:	http://europepmc.org/articles/PMC4259341?pdf=render