The mitochondrial E3 ligase MAPL SUMOylates Drp1 to facilitate mitochondrial fission in intervertebral disc degeneration

Abstract Intervertebral disc degeneration (IVDD) is the primary contributor to a range of spinal diseases. Dynamin-related protein 1 (Drp1)-mediated mitochondrial fission has recently been identified as a new cause of nucleus pulposus cell (NPC) death and IVDD, but the underlying mechanisms remain u...

وصف كامل

التفاصيل البيبلوغرافية
الحاوية / القاعدة:Bone Research
المؤلفون الرئيسيون: Zhidi Lin, Xiao Lu, Guangyu Xu, Jian Song, Hongli Wang, Xinlei Xia, Feizhou Lu, Jianyuan Jiang, Wei Zhu, Zuochong Yu, Xiaosheng Ma, Fei Zou
التنسيق: مقال
اللغة:الإنجليزية
منشور في: Nature Publishing Group 2025-08-01
الوصول للمادة أونلاين:https://doi.org/10.1038/s41413-025-00449-6

الانترنت

https://doi.org/10.1038/s41413-025-00449-6

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