Single-cell analysis reveals altered tumor microenvironments of relapse- and remission-associated pediatric acute myeloid leukemia

Abstract Acute myeloid leukemia (AML) microenvironment exhibits cellular and molecular differences among various subtypes. Here, we utilize single-cell RNA sequencing (scRNA-seq) to analyze pediatric AML bone marrow (BM) samples from diagnosis (Dx), end of induction (EOI), and relapse timepoints. An...

Full description

Bibliographic Details

Published in:	Nature Communications
Main Authors:	Hope Mumme, Beena E. Thomas, Swati S. Bhasin, Upaasana Krishnan, Bhakti Dwivedi, Pruthvi Perumalla, Debasree Sarkar, Gulay B. Ulukaya, Himalee S. Sabnis, Sunita I. Park, Deborah DeRyckere, Sunil S. Raikar, Melinda Pauly, Ryan J. Summers, Sharon M. Castellino, Daniel S. Wechsler, Christopher C. Porter, Douglas K. Graham, Manoj Bhasin
Format:	Article
Language:	English
Published:	Nature Portfolio 2023-10-01
Online Access:	https://doi.org/10.1038/s41467-023-41994-0